版主： verdelite， TheMatrix
cellcycle1 写了： 2022年 10月 18日 16:37 新冠病毒，以老鼠为model，
1，原始株，～100% kill
2，O， mild symptom
3，hybrid ～80% kill
第三是这个研究成果？ 什么烂东西，有嘛意义； 如果 1， 2 是事实就够了！
另外老鼠对 pathogen 反应和 人类 不一样很多，仅供参考； 比如引起人拉痢疾的沙门氏菌，人基本可以自愈，属于自限传染病，但老鼠感染会 有更严重的 Typhus fevers，会死的，反倒 牛 是更好的 model， 引起 肠的炎性反应，GI tract inflammation，
这个基本原理不对，病毒进入细胞以后， 免疫系统基本无从发挥作用；成熟病毒release 时，N 蛋白在 shell 里边，免疫系统也接触不到。。我的叔叔于勒 写了： 2022年 10月 19日 00:39 波大合成病毒研究是为ADE变种金东浏型铺路 “虽然Omicron的刺突蛋白决定了逃逸疫苗免疫保护的能力，但决定致病性的主要毒力因子位于刺突蛋白以外”
帖子 由 我的叔叔于勒 » 2 分钟前
虽然Omicron的刺突蛋白决定了逃逸疫苗免疫保护的能力，但决定致病性的主要毒力因子位于刺突蛋白以外
这个和GVB今年三月发的一段PPT意思一致 通过N段蛋白的变异 导致ADE的新变种获得在下呼吸道的致病力
这句话翻译过来 意思就是你们丫的MRNA疫苗和高端都白打了 因为MRNA只有S段蛋白的CODE N段蛋白根本不表达
为了覆盖N段蛋白 还得进行曲速运动 马上开发注射含N段蛋白的MRNA加强针
cellcycle1 写了： 2022年 10月 19日 00:43 这个基本原理不对，病毒进入细胞以后， 免疫系统基本无从发挥作用；成熟病毒release 时，N 蛋白在 shell 里边，免疫系统也接触不到。。
cellcycle1 写了： 2022年 10月 19日 00:43 这个基本原理不对，病毒进入细胞以后， 免疫系统基本无从发挥作用；成熟病毒release 时，N 蛋白在 shell 里边，免疫系统也接触不到。。
cellcycle1 写了： 2022年 10月 19日 00:20 carwash/jump, 一块回一下，你们要是 看第一帖和题目，这是 一个 open discussion 的楼 ；
除了致病性，你们都 提到 转染性，你们的意思大概是 synergistic effect，如果这个存在，那是有 gain function 嫌疑；
我早早对gain function 的反对在旧mit 就是挂号的； 对这个研究，我的基本态度和这两位差不多；
“不过，这项研究已招致其他科学家的批评。以色列政府首席科学家夏皮洛 (Shmuel Shapira)说：“这是在玩火，这应该全面禁止。”英国东英吉利大学微生物学教授利弗莫尔则说：“鉴于新冠病毒大流行很可能起源于武汉实验室操纵的冠状病毒逃脱，这些实验似乎非常不明智。”
我刚才还找到了，BU 的正式回应，分享一下：
https://www.bu.edu/articles/2022/neidl- ... id-strain/
（全文）
摘：
The study set out to examine the spike proteins on the SARS-CoV-2 Omicron variant (BA.1). Researchers were interested in comparing the variant with the original virus strain, known as the Washington strain. They wanted to find out if the virus was truly less virulent, says Corley, “simply because it wasn’t infecting the same cells as the initial strain.” They were “interested in what part of the virus dictates how serious of a disease a person will get.”
But Corley says the news reports pulled one line from the paper’s abstract out of context, with the Daily Mail suggesting in its headline that the researchers had created a “deadly Covid strain with an 80 percent kill rate.” The newspaper went on to make a series of other misleading claims, including that the study was “gain of function research,” alleging researchers set out to make a more deadly virus.
Not true, says Corley. And the University’s statement strongly denied it.
“We want to address the false and inaccurate reporting about Boston University COVID-19 research, which appeared today in the Daily Mail,” said the BU statement. “First, this research is not gain-of-function research, meaning it did not amplify the Washington state SARS-CoV-2 virus strain or make it more dangerous. In fact, this research made the virus replicate less dangerous.”
Corley says the line pulled out of context actually had nothing to do with the virus’ effect on humans. The study began in a tissue culture, then moved to an animal model.
“The animal model that was used was a particular type of mouse that is highly susceptible, and 80 to 100 percent of the infected mice succumb to disease from the original strain, the so-called Washington strain,” says Corley. “Whereas Omicron causes a very mild disease in these animals.”
That 80 percent number is what the media reports latched onto, misrepresenting the study and its goals.
“This was a statement taken out of context for the purposes of sensationalism,” says Corley, “and it totally misrepresents not only the findings, but [also] the purpose of the study.”
In fact, according to BU’s statement, “this research mirrors and reinforces the findings of other, similar research performed by other organizations, including the FDA.” That’s supported by one of the lead researchers on the study, Mohsan Saeed, a NEIDL investigator.
“Consistent with studies published by others, this work shows that it is not the spike protein that drives Omicron pathogenicity, but instead other viral proteins,” says Saeed, a BU Chobanian & Avedisian School of Medicine assistant professor of biochemistry. “Determination of those proteins will lead to better diagnostics and disease management strategies.”
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小编应该是 搞到了 草稿的abstract， 看看 是否能过 peer review， 发出来啥样吧！
如果发生，地球人正好解套，瘪乐疯了！美帝被全世界声讨 ！Carwash 写了： 2022年 10月 19日 09:56 我查了一下波士顿大学的P4实验室的安全事故记录，发现他们的P4实验室，最近几个月出现了很多事故，包括老鼠咬伤事故，刀片刮伤事故，烧伤事故，生物防护服撕裂事故，各种各样的事故，实验室管理混乱，事故频繁，绝对有可能把病毒泄露出来。
