• Block other co-inhibitory: LAG3, TIM3, KIR, VISTA
• Activate co-stimulatory: 4-1BB, OX-40, GITR, CD27, ICOS
• Block inhibitory molecules- IDOi, TGFbi, CSF1Ri, anti-IL-6 or anti- IL-10
• Effect trafficking- anti-VEGF, CCL5, CXCR4i
• Vaccines- TVEC- oncolytic virus, Neoantigen, other cellular
• Adoptive Cellular therapy- TIL, CAR-T cells, TCR T-cells
• Signal Inhibition, BRAF directed (BRAFi+MEKi), MEKi, PI3K inhibition (PTEN effects)
• Cytokines- IL-2, IFN a,b,g,, Directed cytokines (FAP-IL-2v or CEA-IL-2v)
• Epigenetic modulation- gene expression and EVR expression
• Microbiome modification- fecal transplants
• Chemotherapy other cytotoxics
• Localized Irradiation SBRT, SRS
